ABSTRACT
Abstract: Papular elastorrhexis is an acquired disease of elastic tissue; considered rare, its etiology and pathogenesis remain unknown. The vast majority of cases occur in women in the first or second decade of life. The disease manifests as multiple uniformly-sized, circumscribed, hypochromic and achromic papules located predominantly on the trunk and upper extremities. The lesions are generally asymptomatic and have a stable evolution over years. Its diagnosis is based on clinical and histopathological findings. The benignity of papular elastorrhexis and the subtlety of its clinical changes make the expectant treatment perfectly viable. The authors present one case in a young female patient.
Subject(s)
Humans , Female , Adult , Skin Diseases/pathology , Connective Tissue Diseases/pathology , Elastic Tissue/pathologyABSTRACT
PURPOSE: To present a rat model of subcutaneous endometriosis for the study of pathophysiology and the effects of drugs. METHODS: Fifty three-month-old female Wistar rats (Rattus norvergicus) were distributed into one control group and four treatment groups: estradiol (2.5; 5; 10mg/kg sc), medroxyprogesterone acetate (0.5; 2; 5mg/kg sc), triptorelin pamoate (0.18; 0.56mg/kg sc) and acetylsalicylic acid (3mg/kg per os). The animals were autoimplanted subcutaneously with 4x4-mm uterine fragments to induce endometriosis. The endometriomas were measured on days 1, 7, 14 and 21. The relative dry and wet weights of the endometrioma were used to evaluate response to the drug. Endometrial -like tissue was confirmed by histology. The greatest weight gain was observed on day 14 (relative wet weight: 29.1 ± 6.7mg%, relative dry weight: 5.3 ± 0.9mg %). Treatments were administered between day 5 and day 14. RESULTS: The relative wet weight of the hemiuterus in the 10mg/kg estradiol group differed significantly from control and the other two estradiol groups (p=0.0001). In the medroxyprogesterone acetate group the weight decreased significantly but this decrease was not dose-dependent. Weight reduction was also significant in the triptorelin pamoate and the acetylsalicylic acid groups. CONCLUSION: The model of subcutaneous endometriosis is reproducible, low-cost and easy to perform, and suitable for the study of pathophysiology and the effects of drugs. .
Subject(s)
Animals , Female , Connective Tissue Diseases/drug therapy , Connective Tissue Diseases/physiopathology , Disease Models, Animal , Endometriosis/drug therapy , Endometriosis/physiopathology , Subcutaneous Tissue , Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Antineoplastic Agents, Hormonal/administration & dosage , Aspirin/administration & dosage , Connective Tissue Diseases/pathology , Dose-Response Relationship, Drug , Endometriosis/pathology , Estradiol/administration & dosage , Estrogens/administration & dosage , Medroxyprogesterone Acetate/administration & dosage , Rats, Wistar , Reproducibility of Results , Time Factors , Triptorelin Pamoate/administration & dosageABSTRACT
The aim of this article is to report the case of a 23-year-old female patient that sought dental service for examination of an asymptomatic slow-growing large lump in the mandibular gingiva causing displacement of the right first molar. Excisional biopsy, histopathological analysis, Alcian blue/periodic acid-Schiff (PAS) staining and immunohistochemistry analysis for S-100 were performed. The diagnosis established was oral focal mucinosis. After three years, the patient is still under follow-up, without any recurrences. Although cases of oral focal mucinosis of this particular size are rare, this entity should be considered in the differential diagnosis of oral lesions located in the gingiva...
O objetivo deste artigo é relatar o caso de uma paciente de 23 anos de idade que procurou o serviço odontológico para exame de um grande nódulo de crescimento lento, assintomático, na gengiva mandibular, o que causou deslocamento do primeiro molar direito. Foram realizadas biópsia excisional, análise histopatológica, coloração Alcian blue/periodic acid-Schiff (PAS) e análise imuno-histoquímica para S-100. O diagnóstico de mucinose oral focal foi estabelecido. A paciente ainda está sob acompanhamento, sem recorrência, após três anos. Embora os casos de mucinose oral focal com esse tamanho sejam raros, esta entidade deve ser considerada no diagnóstico diferencial das lesões orais localizadas em gengiva...
Subject(s)
Humans , Female , Young Adult , Alcian Blue , Mucinoses/pathology , Mouth Mucosa/pathology , Diagnosis, Differential , Connective Tissue Diseases/pathologyABSTRACT
To study the different patterns of cutaneous vasculitides along with their underlying etiologic factors and to assess the clinicopathological correlation. A cross sectional study was conducted on 30 consecutive patients, histologically diagnosed as cutaneous vasculitis in the department of dermatology and venereology, BSMMU, Dhaka. All patients were subjected to a baseline workup consisting of complete hemogram, serum-creatinine levels, liver function tests, chest X-ray, urine [routine and microscopic] examination besides antistreptolysin O titer, antinuclear antibody assay, rheumatoid factor assay, antineutrophilic cytoplasmic antibodies and hepatitis B and C. Histopathological examination was done in all patients while immunofluorescence was done in 9 patients. Out of a total of 30 patients diagnosed histologically as cutaneous vasculitis, 22 were classified as cutaneous small vessel vasculitis [CSVV], 6 as Heinoch-Schonlein purpura, and one each as urticarial vasculitis, and Behcet's syndrome. Approximately 30% of the patients had a significant drug history, 23.3% were attributed to infection. No cause was found in 46.7% cases. Only 9 patients could undergo direct immunofluorescence [DIF], out of which 4 were positive for vasculitis. Cutaneous small vessel vasculitis was the commonest type of vaculitis presenting to the dermatology outpatient department. The workup of patients with cutaneous vasculitis includes detailed history, clinical examination and investigations to rule out multisystem involvement followed by skin biopsy and DIF at appropriate stage of evolution of lesions. Follow up of these patients is very essential as cutaneous manifestations may be the formc fruste of serious systemic involvement
Subject(s)
Humans , Male , Female , IgA Vasculitis/etiology , Vasculitis, Leukocytoclastic, Cutaneous/diagnosis , Antibodies, Antinuclear , Rheumatoid Factor , Fluorescent Antibody Technique, Direct , Liver Function Tests , Connective Tissue Diseases/pathology , Cross-Sectional StudiesABSTRACT
Infection of the larval form (cysticerco) of Taenia in any tissue or organ is known as the disease cysticercosis. Many sites of infection have been documented but the central nervous system has been the most common. It present a case report of a 19 years old patient with a subcutaneous cysticercosis confirmed with biopsy.
La infección por la forma larvaria (cisticerco) de Taenia solium en cualquier tejido u órgano se conoce como cisticercosis. Existen numerosos reportes de casos, siendo la mayoría de ellos cisticercos en sistema nervioso central. El compromiso de otros órganos es raramente detectado. Se presenta el caso de una mujer de 19 años con una cisticercosis subcutánea que fue confirmada con biopsia.
Subject(s)
Animals , Female , Humans , Young Adult , Cysticercosis , Connective Tissue Diseases/parasitology , Cysticercus/isolation & purification , Subcutaneous Tissue/parasitology , Biopsy , Connective Tissue Diseases/pathology , Cysticercosis/pathologyABSTRACT
Although autoantibodies are routinely screened in patients with idiopathic interstitial pneumonia, there are no reliable data on their clinical usefulness. The aim of this study was to investigate the prognostic value of autoantibodies for predicting the development of new connective tissue disease in these patients and also mortality. We conducted retrospective analysis of the baseline, and follow-up data for 688 patients with idiopathic interstitial pneumonia (526 with idiopathic pulmonary fibrosis, 85 with nonspecific interstitial pneumonia, and 77 with cryptogenic organizing pneumonia) at one single tertiary referral center. The median follow-up period was 33.6 months. Antinuclear antibody was positive in 34.5% of all subjects, rheumatoid factor in 13.2%, and other specific autoantibodies were positive between 0.7%-6.8% of the cases. No significant difference in patient survival was found between the autoantibody-positive and -negative groups. However, the presence of autoantibodies, especially antinuclear antibody with a titer higher than 1:320, was a significant predictor for the future development of new connective tissue diseases (relative risk, 6.4), although the incidence was low (3.8% of all subjects during follow-up). In conclusion, autoantibodies are significant predictors for new connective tissue disease development, although they have no prognostic value.
Subject(s)
Aged , Female , Humans , Male , Middle Aged , Antibodies, Antinuclear/blood , Autoantibodies/blood , Cohort Studies , Connective Tissue Diseases/pathology , Follow-Up Studies , Idiopathic Interstitial Pneumonias/blood , Prognosis , Retrospective Studies , Rheumatoid Factor/blood , Risk Factors , Tertiary Care Centers , Tomography, X-Ray ComputedABSTRACT
Background & objectives: Cutaneous vasculitis has protean clinical manifestations. It may be idiopathic or associated with a spectrum of conditions such as infections, drugs, etc. Skin is involved in both small vessel vasculitis (SVV) and medium vessel vasculitis (MVV). Overlapping features are seen between SVV and MVV. The histopathological features may not always relate with the clinical lesions. The aim of the present study was to evaluate the aetiological factors and clinicopathological association in patients with cutaneous vasculitis. Methods: In this cross-sectional study, detailed history and clinical examination were done on patients with biopsy proven cutaneous vasculitis. Two skin biopsies were taken from each patient for routine histopathology and direct immunofluorescence. Results: Of the 61 patients studied, hypersensitivity vasculitis (HSV) [23 (37.7%)] and Henoch Schonlein purpura (HSP) [16 (26.2%)] were the two most common forms. Systemic involvement was seen in 32 (52.45%) patients. Drugs were implicated in 12 (19.7%) cases, infections in 7 (11.4%) and connective tissue disorders in 4 (6.5%) cases. Histologically SVV was the most common pattern, seen in all the clinically diagnosed patients with SVV (47), and in 12 of the 14 clinically diagnosed patients with MVV. Direct immunofluorescence showed positivity for at least one immunoreactant in 62 per cent of the patients and the most common deposit was C3 followed by IgG, IgA and IgM. Interpretation & conclusions: Majority of our patients with cutaneous vasculitis were idiopathic. Histologically, SVV was seen in most of our patients. No association was seen between history of drug intake and tissue eosinophilia and also between histologically severe vasculitis and clinical severity. The presence of immunoreactant IgA was not specific for HSP.
Subject(s)
Biopsy , Blood Vessels/pathology , Connective Tissue Diseases/blood , Connective Tissue Diseases/diagnosis , Connective Tissue Diseases/etiology , Connective Tissue Diseases/pathology , Diagnosis, Differential , Female , Humans , Male , Microscopic Polyangiitis/blood , Microscopic Polyangiitis/diagnosis , Microscopic Polyangiitis/etiology , Microscopic Polyangiitis/pathology , IgA Vasculitis/blood , IgA Vasculitis/diagnosis , IgA Vasculitis/etiology , IgA Vasculitis/pathology , Vasculitis, Leukocytoclastic, Cutaneous/blood , Vasculitis, Leukocytoclastic, Cutaneous/diagnosis , Vasculitis, Leukocytoclastic, Cutaneous/etiology , Vasculitis, Leukocytoclastic, Cutaneous/pathologyABSTRACT
Os autores relatam trés casos de hamartoma fibroso da infância (HFI), tumor raro que corresponde a cerca de 2 por cento dos tumores de tecido conjuntivo na faixa pediátrica. Acomete crianças nos dois primeiros anos de vida, com predomínio para o sexo masculino. É geralmente reconhecido como uma entidade benigna, porém sua variabilidade histológica pode provocar dificuldade diagnóstica com lesöes de comportamento mais agressivo e eventual tratamento radical.
Subject(s)
Humans , Male , Infant , Connective Tissue Diseases/diagnosis , Hamartoma/diagnosis , Connective Tissue Diseases/pathology , Hamartoma/pathologyABSTRACT
Os autores fazem uma breve revisäo da literatura acerca da Elastose Perfurante Serpiginosa, em seguida apresentam um caso da doença incidindo em paciente do sexo masculino
Subject(s)
Humans , Male , Adolescent , Connective Tissue Diseases/pathology , Elastic Tissue/pathologyABSTRACT
Se llevó a cabo la investigación cumpliendo con un protocolo dirigido al estudio de los cambios hepáticos por los métodos clínicos y de laboratorio que incluía pruebas bioquímicas hepáticos, inmunológicas y el estudio histopatológico. Se seleccionaron 11 pacientes con diagnóstico confirmado de enfermedades de tejido conectivo, de un gran grupo de 89 pacientes a los cuales se les había practicado estudios histopatológicos de hígado y que tenía otras enfermedades distintas a las enfermedades del tejido conectivo o reumáticas. Los resultados de esta investigación demuestran que hubo alta coincidencia entre los diagnósticos de ingreso y egresos en cuanto a las enfermedades del tejido conectivo se refiere, no así en relación con el diagnóstico de ALTERACION HEPATICA, LA CUAL CON EL ESTUDIO HISTOPATOLOGICO DEMOSTRARON CAMBIOS, SOSPECHOSOS SOLO PACIENTE POR LOS OTROS METODOS. Los cambios histopatológicos estuvieron constituidos por Estiatosis de leve a moderada, Fibrosis discreta, hepatitis leve hasta la forma de hepatitis crónica persistente. Solo 1 caso de los 11 fue normal, Granulomatosis de Wegener, no ubicada como enfermedad del tejido conectivo por la mayoría de los autores. Se concluye que se requiere del estudio histopatológico (biopsia hepática) en aquellos pacientes con enfermedad reumática donde existe sospecha por clínica, pruebas bioquímicas hepáticas o inmunológicas de tener una hepatopatía y poder establecer una interrelación. Se requiere de más estudios en el futuro, incluyendo la ultraestructura para poder establecer, los criterios de un asociación etiopatogénica
Subject(s)
Humans , Male , Female , Autoimmune Diseases/pathology , Connective Tissue Diseases/pathology , Liver Diseases/pathologyABSTRACT
La capilaroscopia in vivo del pliegue ungueal proximal de los dedos de las manos es un procedimento simple, no invasivo, con una sensibilidad y especificidad notables que lo convierten en una ayuda muy util en la valoracion de pacientes con enfermedades del tejido concetivo. Fueron examinados 65 pacientes con esclerosis sistemica progresiva, lupus eritematoso sistemico, dermattomiositis, fenomeno de Raynaud primario o artritis reumatoide. Los resultados confirman la ocurrencia de patrones caracteristicos de algunas entidades: el patron SD fue encontrado en todos los casos de dermatomiositis en 93% de esclerosis y en 80% de fenomeno de Raynaud primario. En la artritis reumatoide no existe un patron particular bien definido por lo que quizas la capilaroscopia es menos util. El seguimiento capilaroscopico de los pacientes con fenomeno de Raynaud primario puede predecir el desarrollo ulterior de una enfermedad sistemica del tejido concetivo.